Soluble VEGFR1 reverses BMP2 inhibition of intramembranous ossification during healing of cortical bone defects
نویسندگان
چکیده
منابع مشابه
Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects.
Assessing modes of skeletal repair is essential for developing therapies to be used clinically to treat fractures. Mechanical stability plays a large role in healing of bone injuries. In the worst-case scenario mechanical instability can lead to delayed or non-union in humans. However, motion can also stimulate the healing process. In fractures that have motion cartilage forms to stabilize the ...
متن کاملHealing Large Bone Defects
Large bone defects and non-union fractures, especially in the diaphysis, represent a challenging and complex interaction of mechanical and biological factors. Fortunately, many of these problem fractures can be successfully managed by stabilization and autologous cancellous bone grafting. However, in some patients autologous cancellous bone graft collection can be associated with morbidity, or ...
متن کاملHealing Large Bone Defects
Large bone defects and non-union fractures, especially in the diaphysis, represent a challenging and complex interaction of mechanical and biological factors. Fortunately, many of these problem fractures can be successfully managed by stabilization and autologous cancellous bone grafting. However, in some patients autologous cancellous bone graft collection can be associated with morbidity, or ...
متن کاملThe Use of Tail Vertebra as Cortical Bone Graft in Experimentally Induced Ulnar Defects in Dogs
Objective- To evaluate tail vertebra as an autogenous cortical bone and cancellous bone for filling ulnarsegmental bone defect in dogs.Design- Experimental study.Animals- Eight adult mongrel dogs with an aver age age of 37.S months and average body wei ght of17.62 kg.Procedure- Th e animals were randomly divided into two groups . A bone defect (2.S-cm) was created onthe middle po rtion of the r...
متن کاملVascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover.
Several growth factors are expressed in distinct temporal and spatial patterns during fracture repair. Of these, vascular endothelial growth factor, VEGF, is of particular interest because of its ability to induce neovascularization (angiogenesis). To determine whether VEGF is required for bone repair, we inhibited VEGF activity during secondary bone healing via a cartilage intermediate (endoch...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2016
ISSN: 0736-0266
DOI: 10.1002/jor.23416